Cefamandole facts

Precautions are to be taken in Renal disease when the dose of the drug needs to be reduced, say experts.

Systems: General (Systemic) 
Category: Second Generation Cephalosporin 

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Pharmacokinetics 

Cefamandole attains high concentration in bile and is excreted in the urine as such .

Indications

Cephamandole is more effective against gram negative organisms including Enterobacter, Klebsiella and Proteus and less active against Gram positive organisms than first generation Cephalosporins .

Routes of Administration and Dosage

For bacterial infections: Injection dose: Adults: 500 milligrams (mg) to 2 grams every four to eight hours, injected IV or IM.

Contra Indications

Cefamandole is contraindicated in pregnancy, lactation and hypersensitivity to cephalosporins.

Precautions

Precautions are to be taken in Renal disease when the dose of the drug needs to be reduced and when diuretics are used concurrently.

Interactions

Probenecid may increase the blood level of Cefamandole. Concurrent use of diuretic with Cefamandole may increase the nephrotoxicity.

(Source: Webhealthcentre.com)