The 33-year-old actress got her big break playing popular character Dr Izzie Stevens for six years on the hit US medical drama.
She was dogged by rumours of a rift with co-stars and producers following her success in 2007 movie Knocked Up, and she finally left the series after adopting her daughter Naleigh in late 2009.
Heigl has carved out a big screen career since her departure, but she has now declared her desire to return to the show because she is desperate to find out what happened to her character, reported E!Online.
"I've told them (show bosses) I want to. (But they have) about 40 different storylines, so I don't know if it fits in to their sort of vision for this season or next or however many seasons it goes. I really, really, really want to see where she (character) is. I just want to know what happened to her, and where she went, and what she's doing now," Heigl said.
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