Mounjaro arrives in India: Game-changer or not?
Mounjaro, a weekly injection, targets GIP and GLP-1 hormones to enhance insulin release and appetite regulation, aiding weight loss alongside diabetes treatment
The Ozempic craze is not yet over. Originally developed for type 2 diabetes, the drug that took celebrities and social media by storm for its weight loss effects now has a new competitor in the Indian market. Enter Eli Lilly, an American pharmaceutical company, which launched Mounjaro (tirzepatide) in India last week on March 20.
How does it work?
Mounjaro works by targeting two key hormones — GIP (Glucose-Dependent Insulinotropic Polypeptide), which enhances insulin release from the pancreas in response to food intake, and GLP-1 (glucagon-like peptide-1), which regulates blood sugar levels by stimulating insulin secretion and reducing glucagon release. This once-a-week injection has been approved by India’s drug regulatory authority for the treatment of type 2 diabetes.
“Mounjaro’s ability to regulate appetite, improve insulin sensitivity, and reduce liver sugar production sets it apart from other diabetes medications,” informs Dr Sharwari Dabhade, endocrinologist at Madhukar Rainbow Children’s Hospital.
On weight loss
Mounjaro is primarily for people with type 2 diabetes but is also prescribed for obesity. Mounjaro's weight loss mechanism is closely tied to its effect on appetite regulation. “Activating GLP-1 and GIP receptors, it helps reduce hunger and increase feelings of fullness, making it easier to eat smaller meals and stick to a healthy diet. It increases insulin sensitivity, helping the body use insulin more effectively and reducing insulin resistance,” adds Dr Sharwari.
Who can take it?
According to Dr Rashi Chahal, nutritionist at La femme Hospital, it is recommended for adults struggling with blood sugar control despite lifestyle modifications. However, certain individuals should avoid it, including:
•Those with a history of pancreatitis
•People with type 1 diabetes
•Pregnant or breastfeeding women (safety data is limited)
•Patients with severe kidney or heart disease should consult their doctor before starting the medication.
"Studies show that Mounjaro can support weight loss even in people without diabetes. Some users have lost up to 13% of their body weight over several months. However, it is not yet officially approved for obesity treatment alone, so it should only be used under medical supervision,” she adds.
Side effects and risks
Like any medication, Mounjaro comes with potential side effects. Common ones include nausea, vomiting, and diarrhea. In rare cases, it may cause pancreatitis or thyroid issues. “Regular monitoring of a patient is important while on this medication mixed with a good and healthy diet that includes all the nutrients,” says Dr Manoj Kumar Agrawal, Consultant Endocrinologist at Shalby Hospital, adding, “Rapid weight loss can also lead to muscle loss and nutritional deficiencies if not managed properly. Blood sugar levels, kidney function, and any potential side effects should be monitored to ensure safety. Consulting a doctor regularly helps track progress and adjust the dosage if needed.”
Does it have a long-term solution?
While Mounjaro can help manage diabetes and obesity, it should not be the sole solution. A balanced diet, regular exercise, and lifestyle changes remain crucial for long-term health. Medications can support weight loss and blood sugar control, but sustainable results require a holistic approach.
“Mounjaro is a promising treatment option, but its usage should be tailored to individual health needs and supervised by healthcare professionals only,” notes Dr Rashi.
Mounjaro vs Ozempic
- Mounjaro
Pros:
- Studies show Mounjaro reduces HbA1C levels more effectively than Ozempic
- People can lose up to 20–25% of body weight
- Once-weekly injection makes it convenient for long-term use.
Cons:
- Higher risk of nausea and vomiting, as some patients report stronger gastrointestinal side effects.
- Affordability may be a concern in India.
- It’s only approved for type 2 diabetes and weight loss
Price: ₹4,375 ($50.67) for a 5 mg vial, ₹3,500 ($40.54) for a 2.5 mg vial. It is available in India.
2. Ozempic
Pros:
- Has been in use longer with well-documented results.
- More accessible for patients managing diabetes.
- Good for mild to moderate weight loss. It works effectively but with slightly less impact than Mounjaro
Cons:
- Less effective for weight loss as some people may not experience as much weight reduction.
- Rapid weight loss can cause facial sagging.
- Like Mounjaro, it can cause nausea, bloating, and diarrhea.
Price: The injectable Ozempic can cost between ₹8,000 and ₹20,000 a shot.
