Alcacer also injured his knee in the first-half of last Friday’s disappointing 3-3 draw at home to Bundesliga bottom club Paderborn, when the hosts were three goals down at half-time.
De Jong is proud to join the likes of compatriots Ronald Koeman, Frank de Boer and Patrick Kluivert in heading to the Nou Camp, having dreamed of wearing Barca colours.
Godin, 33, has played 387 times for Atletico since joining from Villarreal in 2010, scoring 27 goals - including famously clinching the club’s first La Liga title in 18 years with a header in a 1-1 draw at Barcelona in 2014.
In the other semi-final, last year’s runners-up Liverpool head to the Nou Camp to play Barcelona in the first leg on May 1 with the return leg at Anfield six days later.
Barca trailed 2-0 at halftime and even though Lionel Messi struck twice on his return from injury and Arturo Vidal also scored for the Catalans, Betis became the first side to beat Barca at the Nou Camp since Alaves in September 2016.