Ceftriazone is used in bacterial meningitis, multi-resistant typhoid fever, complicated UTI etc.health and fitness Updated: Feb 14, 2004 14:16 IST
Systems: General (Systemic)
Category: Third Generation Cephalosporin
Ceftriazone is a long acting third generation cephalosporin, with half life of 8 hours. It has a good CSF penetration and eliminated equally in urine and bile.
Ceftriazone is used in bacterial meningitis[espcially in children], multi-resistant typhoid fever, complicated UTI, abdominal sepsis and septicemia. A single dose of 250 mgs I.M has proved curative in gonorrhea including PPNG.
Routes of Administration and Dosage
IN meningitis; 4gms followed by 2gms I.V[children 75-100mgskg] once daily for 7-10 days. Typhoid; 4gms I.V for 2 days followed by 2 gmsday[for children 75 mgskg] till 2 days after the fever subsides.
Ceftriazone is contraindicated in patients with hypersensitivity to cephalosporins.
Hypoprothrombinemia and bleeding are specific adverse effects of cephalosporins. Precautions are to be taken in renal failure.
Ceftriazone gives Disulfiram like reaction with alcohol.
Becef(Alkem), Cefaxone IM(Lupin), Ceftrax(Dee-Pharma), Gramocer(Micro Labs), Gutencef(Merck), Inocef(J.K.Ind), Lyceft(Lyka), MonocefIV(Aristo), Monotax(Biochem), Nosocef(Merind), Odicef(Galpha), Powercef(Wockhardt), Torocef(Torrent), Traxol(Cachet Pharma), Triax( Prem Pharma), Zefone(Cadila Healthcare).