Rheumatoid arthritis is the most common form of inflammatory rheumatism.(AFP)
Rheumatoid arthritis is the most common form of inflammatory rheumatism.(AFP)

Cure for rheumatoid arthritis? Scientists say they are close to breakthrough

A team of researchers at Yale University has identified a genetic mechanism that augments the risk of severe rheumatoid arthritis, an inflammatory auto-immune disease that attacks the joints. Their discovery could pave the way for the development of treatments that take into account patients’ genetic profiles.
By AFP, New York
UPDATED ON NOV 28, 2016 11:42 AM IST

Today treatments such as anti-inflammatories, corticosteroids and immunosuppressive drugs have enabled doctors to stabilize the progress of rheumatoid arthritis, while ongoing research continues in a bid to achieve a long-term adjustment in patients’ immunity that will amount to a cure.

This latest American study focused on the genetic character of this debilitating disease. Along with the deregulation of patients’ immune systems, genetic risk factors can account for 50% of the probability of developing rheumatoid arthritis. In particular, researchers analyzed modifications in the expression of the MIF gene found in the most serious cases.

According to their findings, patients showing a wide variation of MIF genes produce higher quantities of MIF proteins implicated in the development of cancers. They further concluded that this process is also at work on the level of damaged joint cells. The discovery will pave the way for testing MIF pathway inhibitors on rheumatoid arthritis sufferers; such drugs are currently in clinical trials to evaluate their efficacy in the treatment of cancer, and other auto-immune pathologies.

Rheumatoid arthritis is the most prevalent form of inflammatory rheumatism. The illness can occur at any age, however, it is most frequent between the ages of 40 and 60, and often associated with the age of menopause for women. Early rheumatoid arthritis in patients under the age of 30 is four times as common among women. After age 60, prevalence is identical for both sexes. These findings have been published in the “Proceedings of the National Academy of Sciences” (PNAS).

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In a paper published in Biochemical and Biophysical Research Communications, researchers looked at the effect of feeding mice a high-fat diet on oxidative stress levels on heart cells.(Unsplash)
In a paper published in Biochemical and Biophysical Research Communications, researchers looked at the effect of feeding mice a high-fat diet on oxidative stress levels on heart cells.(Unsplash)

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ANI, Washington [us]
PUBLISHED ON MAR 07, 2021 11:48 AM IST
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Vicky Kaushal shares new fitness video(Instagram story/ vickykaushal09)
Vicky Kaushal shares new fitness video(Instagram story/ vickykaushal09)

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Representational Image(Unsplash)
Representational Image(Unsplash)

Here's how green tea is beneficial for children with Down syndrome

ANI, Washington Dc
PUBLISHED ON MAR 06, 2021 07:54 PM IST
According to a new study, green tea supplements modulate facial development in children with Down syndrome.
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Representational Image(Unsplash)
Representational Image(Unsplash)

Here's how unstable work-life linked to future mental health problems in youth

ANI, Washington Dc
PUBLISHED ON MAR 06, 2021 07:41 PM IST
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Type 2 diabetes could be prevented through regular exercise, says study(Photo by Anupam Mahapatra on Unsplash)

Type 2 diabetes could be prevented through regular exercise, says study

ANI
PUBLISHED ON MAR 06, 2021 06:23 PM IST
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Should you eat dates before bed or empty stomach to reap maximum health benefit?(Photos by Saj Shafique and Mona Mok on Unsplash)

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The study highlighted the ways that public health interventions and policies can better support quit attempts and harm reduction, both during the Covid-19 pandemic and beyond.(Pixabay)
The study highlighted the ways that public health interventions and policies can better support quit attempts and harm reduction, both during the Covid-19 pandemic and beyond.(Pixabay)

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ANI, Washington [us]
PUBLISHED ON MAR 06, 2021 12:33 PM IST
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AP, New York
UPDATED ON MAR 06, 2021 07:46 AM IST
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Following a vegan diet leads to poorer bone health? Here's what study has to say(Photo by Louis Hansel @shotsoflouis on Unsplash)

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ANI
UPDATED ON MAR 05, 2021 09:02 PM IST
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Young people with unstable work life might suffer mental health problems later

ANI
UPDATED ON MAR 05, 2021 08:48 PM IST
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Covid-19: Oxford study hint AstraZeneca vaccine effective against Brazil variant(Photo by Ivan Diaz on Unsplash)

Covid-19: Oxford study hint AstraZeneca vaccine effective against Brazil variant

Reuters
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Here’s how you can locate Covid-19 on your skin(Twitter/samrinahashmi)

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By Zarafshan Shiraz
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 (Shutterstock)
(Shutterstock)

Were you up all night again? Tips to help you beat 4 am angst

By Vanessa Viegas
PUBLISHED ON MAR 05, 2021 05:45 PM IST
Arguments you could have navigated better, vital to-dos that you’re not sure you’ve done, the quiet whisperings of an anxious mind — these are a few of our least favourite things
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