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High BP & renal disease

High BP, smoking, diabetes and obesity are associated with kidney disease, says study.

health and fitness Updated: May 18, 2004 01:48 IST

New research shows that cardiovascular disease risk factors, including high blood pressure, smoking, diabetes, and obesity are associated with the development of kidney disease.

According to a study in the February 18 issue of 'The Journal of the American Medical Association' (JAMA), hypertension and diabetes are the leading causes of end-stage renal disease (ESRD).

Among individuals who develop ESRD, the risk of cardiovascular disease is 10 to 20 times higher than the general population, and increased risks are evident even in mild kidney disease."

Approximately, there are 275,000 patients with ESRD in the U.S. and an estimated 8 million additional U.S. adults have kidney disease.

Caroline S. Fox from the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass., and colleagues identified predictors of the development of new-onset kidney disease.

The researchers analyzed data from 1,223 men and 1,362 women in the Framingham Offspring Study who had a baseline examination in 1978 - 1982 and returned for a follow-up examination in 1998 -2001.

None of the participants had kidney disease in the initial examinations. After an average follow-up of 18.5 years, 244 participants (9.4 percent) had developed kidney disease.

The researchers found that established cardiovascular disease risk factors predicted the development of kidney disease.

"In addition, a mildly reduced GFR at baseline increased the odds of developing kidney disease. Our data indicate that among unselected participants, diabetes, hypertension, obesity, smoking, low HDL-C level, and a mild reduction in GFR are important risk factors for the development of new-onset kidney disease," Fox said.

First Published: Feb 18, 2004 21:12 IST