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Obesity hampers fertility: KGMU team

INFERTILITY IN women has a new proven reason. Mutation of Interleukin-6 (IL-6) gene in women resulting into Polycystic Ovarian Syndrome (POS). The finding was the result of a research undertaken by the Department of Physiology at King George?s Medical University on women with controlled, lean and central obesity. The research was done over a hundred women who were unable to conceive.
None | By HT Live Correspondent
PUBLISHED ON JUL 31, 2006 12:59 AM IST

INFERTILITY IN women has a new proven reason. Mutation of Interleukin-6 (IL-6) gene in women resulting into Polycystic Ovarian Syndrome (POS).
The finding was the result of a research undertaken by the Department of Physiology at King George’s Medical University on women with controlled, lean and central obesity. The research was done over a hundred women who were unable to conceive.

The research team found that most of the cases with central or abdominal obesity had got this gene mutated. They came to the conclusion that this IL-6 gene could be another reason for infertility in women during their reproductive age.

Eighteen cases of IL-6 mutation under the study were found to have POS, which is a common heterogeneous disorder characterized by infertility and chronic ovulation problems.

“During the study, it was found that women with central obesity had maximum problem and cases of gene mutation were high in them. Gene mutation was found less in the cases of lean or controlled obesity,” said the project investigator Dr Vani Gupta.

“Women with POS are vulnerable to some other problems also. They may fall victim to the cardiovascular diseases, abnormal blood pressure or other related problems,” Dr Gupta said.

She said further study on the cause of this gene mutation would be done to find ways to control it. If the gene can be saved from mutation in women, infertility may be eradicated from women who fall victim to this particular syndrome.
As per the researchers most of the women do not about this gene mutation and they go for In Vitro Fertilisation or test tube baby technique. However, if they go for a check-up about gene mutation they may conceive normally.

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