A detailed description of how ovarian cancer cells adapt to survive and proliferate in the peritoneal cavity has been published in Frontiers in Oncology.(ANI)
A detailed description of how ovarian cancer cells adapt to survive and proliferate in the peritoneal cavity has been published in Frontiers in Oncology.(ANI)

Ovarian cancer cells adapt to their surroundings to aid tumor growth: Study

A detailed description of how ovarian cancer cells adapt to survive and proliferate in the peritoneal cavity has been published in Frontiers in Oncology.
ANI
PUBLISHED ON JAN 13, 2021 04:23 PM IST

A detailed description of how ovarian cancer cells adapt to survive and proliferate in the peritoneal cavity has been published in Frontiers in Oncology.

Researchers show that structures inside the cells change as the disease progresses from benign to malignant, helping the cells to grow in an otherwise hostile environment of low nutrients and oxygen. Understanding how these cellular adaptations are regulated could herald new targeted treatment options against the fifth-leading cause of cancer-related deaths in women.

"Our study compared the structures inside cells representing different stages of ovarian cancer, including after aggregation, which enhances their survival," says Eva Schmelz, a Professor and Scientific Director at Virginia Tech University, USA, who led this research. "We found that one of these structures, the mitochondria, known as the 'battery pack' of the cell, changed shape and function to adapt to the hostile conditions in the peritoneal cavity, allowing aggressive cancerous cells to grow and take hold."

Fatal spread of cells

Ovarian cancer can often originate from cancerous cells in the fallopian tubes. Cells exfoliating from this cancerous mass can then spread onwards throughout the peritoneal cavity via the fluid in the abdomen. At this stage, a patient's survival rates are just 30%, even if the original tumor is removed.

Chances are greatly increased to over 90 per cent if it is caught in the initial stages, but this cancer is hard to detect because there are very few reliable early biomarkers or symptoms.

"If we understand how ovarian cancer cells survive in the fluid of the abdomen as they spread around the peritoneal cavity, we may be able to develop specific therapeutics and interventions to suppress cancerous outgrowths of cells from the original tumor," explains Schmelz.

"Our previous work has shown the metabolism of cells changed as ovarian cancer progressed. We wanted to build on this by looking inside the cells to see if any structural differences could be seen. By examining cells developed from the ovaries of mice, any changes could be attributed to the progression of the disease rather than any differences between individuals."

The researchers used a wide variety of microscopy techniques to obtain 2D images and 3D models of the mitochondria, to identify and measure their structure at different stages of the cancer.

Adapt to survive

"As ovarian cancer progressed, the mitochondria changed from a filamentous network to that of a highly fragmented form," reports Schmelz. "This fragmentation and known changes in the way mitochondria function in this state, are how the cells adapt to an environment that is low in nutrients and oxygen. It also allows the cells to escape treatments commonly used in ovarian cancer patients, so they can continue to proliferate."

Schmelz's team at Virginia Tech hope these findings will form the basis of research to bring new treatments for this devastating disease.

"Future studies will identify how the changes we have identified inside the cells are regulated by isolating specific cell signalling pathways to create targets for therapies that limit the viability and spread of ovarian cancer cells."

This story has been published from a wire agency feed without modifications to the text.

SHARE THIS ARTICLE ON
app
Close
Representational image(Unsplash)
Representational image(Unsplash)

Novel vaccine that may help prevent future coronavirus pandemics developed

PTI
PUBLISHED ON JAN 15, 2021 04:43 PM IST
The novel 'mosaic nanoparticle' vaccine, described in the journal Science, is shaped like a cage made up of 60 identical proteins, each of which has a small protein tag that functions like a piece of Velcro.
Close
Parineeti Chopra starts her day with Yoga(Instagram/parineetichopra)
Parineeti Chopra starts her day with Yoga(Instagram/parineetichopra)

Parineeti Chopra loves her Yoga mornings, says she is addicted to stretching

By Nishtha Grover, Delhi
PUBLISHED ON JAN 15, 2021 04:09 PM IST
The Girl On The Train star Parineeti Chopra is a fan of doing Yoga in the morning. The actor says that she is "addicted to stretching, breathing deeply and thinking happy thoughts."
Close
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients.(Yahoo)
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients.(Yahoo)

Acute itching in eczema patients linked to environmental allergens

ANI
UPDATED ON JAN 15, 2021 02:52 PM IST
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients.
Close
Use of the diabetes drug metformin, before a diagnosis of Covid-19 is associated with a threefold decrease in mortality in Covid-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham.(Yahoo)
Use of the diabetes drug metformin, before a diagnosis of Covid-19 is associated with a threefold decrease in mortality in Covid-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham.(Yahoo)

Metformin use reduces risk of death for patients with Covid-19, diabetes

ANI
PUBLISHED ON JAN 15, 2021 01:43 PM IST
Use of the diabetes drug metformin, before a diagnosis of Covid-19 is associated with a threefold decrease in mortality in Covid-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham.
Close
A study quantifies the disparate impacts of Covid-19 on life expectancy in the United States on the basis of racial and ethnic disparities.(Unsplash)
A study quantifies the disparate impacts of Covid-19 on life expectancy in the United States on the basis of racial and ethnic disparities.(Unsplash)

Racial, ethnic disparities in Covid-19 impact on life expectancy

ANI
UPDATED ON JAN 15, 2021 01:12 PM IST
A study quantifies the disparate impacts of Covid-19 on life expectancy in the United States on the basis of racial and ethnic disparities.
Close
Disha Patani's new exercise video will make you jaws hit the floor(Instagram/dishapatani)
Disha Patani's new exercise video will make you jaws hit the floor(Instagram/dishapatani)

Watch: Disha Patani's new exercise video will make your jaws hit the floor

By Nishtha Grover, Delhi
PUBLISHED ON JAN 15, 2021 09:09 AM IST
  • Disha Patani recently shared a clip that shows the actor landing an impressive flying kick on a boxing bag. This is all the motivation that we will need to start our weekend on a fitter note.
Close
A new paper in Q Open finds that the availability of fast-food restaurants on the route between children's houses and their schools does not affect children's weight.(ANI)
A new paper in Q Open finds that the availability of fast-food restaurants on the route between children's houses and their schools does not affect children's weight.(ANI)

Fast food restaurant proximity likely doesn't affect children's weight: Study

ANI
PUBLISHED ON JAN 14, 2021 05:48 PM IST
A new paper in Q Open finds that the availability of fast-food restaurants on the route between children's houses and their schools does not affect children's weight.
Close
As soon as bird flu cases were reported in the city, ducks at Sanjay Lake Park and other parks were inspected/culled by health workers. (Photo: ANI)
As soon as bird flu cases were reported in the city, ducks at Sanjay Lake Park and other parks were inspected/culled by health workers. (Photo: ANI)

Bird flu scare and non veg cravings? Wary Delhiites look for safe food options

By Mallika Bhagat
PUBLISHED ON JAN 14, 2021 05:36 PM IST
Amid Covid-19 and now Bird Flu scare, Delhiites are turning to vegetarian options to fulfil their protein requirements while ensuring they stay safe.
Close
Esha Gupta does extremely difficult asana with utmost ease(Instagram/egupta)
Esha Gupta does extremely difficult asana with utmost ease(Instagram/egupta)

Esha Gupta does extremely difficult asana with utmost ease, we are speechless

By Nishtha Grover, Delhi
PUBLISHED ON JAN 14, 2021 03:58 PM IST
  • In her latest fitness post, Esha Gupta can be seen doing an extremely tough variation of Baddha Konasana. The actor always manages to leave us speechless with her Yoga posts and this one is no different.
Close
Decades of research show that depression, stress, loneliness, and poor health behaviors can weaken the body's immune system and lower the effectiveness of certain vaccines.(Unsplash)
Decades of research show that depression, stress, loneliness, and poor health behaviors can weaken the body's immune system and lower the effectiveness of certain vaccines.(Unsplash)

Study: Depression, stress could dampen efficacy of Covid-19 vaccines

ANI
UPDATED ON JAN 14, 2021 03:38 PM IST
Decades of research show that depression, stress, loneliness, and poor health behaviors can weaken the body's immune system and lower the effectiveness of certain vaccines.
Close
Researchers said the worms, either eaten whole or in powdered form, are a protein-rich snack or ingredient for other foods.(Unsplash)
Researchers said the worms, either eaten whole or in powdered form, are a protein-rich snack or ingredient for other foods.(Unsplash)

Cafe, croissant, worms? EU agency says worms safe to eat

AP, Rome
PUBLISHED ON JAN 14, 2021 03:31 PM IST
The vaunted Mediterranean diet and French gastronomy are getting some competition: The European Union's food safety agency says worms are safe to eat.
Close
REM sleep correlates when we dream. Our eyes move back and forth, but our bodies remain still. This near-paralysis of muscles while dreaming is called REM-atonia and is lacking in people with REM sleep behaviour disorder.(Unsplash)
REM sleep correlates when we dream. Our eyes move back and forth, but our bodies remain still. This near-paralysis of muscles while dreaming is called REM-atonia and is lacking in people with REM sleep behaviour disorder.(Unsplash)

Researchers find how the brain paralyses you while you sleep

ANI, Tsukuba [japan]
PUBLISHED ON JAN 14, 2021 02:35 PM IST
Researchers at the University of Tsukuba have found neurons in the brain that link, narcolepsy, cataplexy, and rapid eye movement (REM) sleep behaviour disorder disorders and could provide a target for treatments.
Close
Since the pandemic’s descent, they have generally been viewed as among those at higher risk — older Americans, some of them medically vulnerable, figuring out how to navigate life in a Covid-saturated, increasingly isolated world.(Unsplash)
Since the pandemic’s descent, they have generally been viewed as among those at higher risk — older Americans, some of them medically vulnerable, figuring out how to navigate life in a Covid-saturated, increasingly isolated world.(Unsplash)

Study: In pandemic era, older adults isolated but resilient

AP
PUBLISHED ON JAN 14, 2021 12:22 PM IST
When it comes to mental and emotional health, older adults in the United States are showing resilience and persevering despite struggles with loneliness and isolation.
Close
Nurses work with patients inside the Intensive Care Unit at St George's Hospital in London, (AP)
Nurses work with patients inside the Intensive Care Unit at St George's Hospital in London, (AP)

Coronavirus: Critical care staff suffer trauma, severe anxiety due to Covid-19

Reuters
PUBLISHED ON JAN 13, 2021 06:44 PM IST
Nearly half of staff working in intensive care units (ICU) in England in the COVID-19 pandemic have severe anxiety, depression or post-traumatic stress disorder, with some reporting feeling they'd be better off dead, according to a study published on Wednesday.
Close
In a large population-based family study, family history of kidney disease was strongly associated with increased risk of chronic kidney disease.(ANI)
In a large population-based family study, family history of kidney disease was strongly associated with increased risk of chronic kidney disease.(ANI)

First-degree relative with kidney disease increases risk by three-fold

ANI
PUBLISHED ON JAN 13, 2021 05:22 PM IST
In a large population-based family study, family history of kidney disease was strongly associated with increased risk of chronic kidney disease.
Close
SHARE
Story Saved
OPEN APP