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Body mass effects response to asthma medications

Researchers revealed that different asthma medications have different effects on people of different body masses.

india Updated: Feb 24, 2006 12:01 IST

Researchers revealed that different asthma medications have different effects on people of different body masses.

Inhaled steroids work better for lean people than on obese asthma patients while Singulair a pill has a better effect on obese people, as compared to their leaner counterparts. The was conducted by the University of Michigan Medical School and was published in the new issue of the European Respiratory Journal.

The study suggests that people who are overweight or obese may have better results with the prescription pill sold as Singulair than with a type of inhaled steroid, while leaner people may have better luck with an inhaled steroid, called beclomethasone and sold as beclovent, vanceril and other brand names.

"It is increasingly recognized that obese people are more prone to develop asthma, but there is no information about whether obesity influences people's responses to particular asthma medications," says lead author Marc. "Our findings are the first to suggest the possibility that obesity might be a factor that influences how well asthmatics respond to particular medications," Peters-Golden says.

The inhaled steroid fared better than Singulair at improving the number of asthma control days (ACD) among people in the normal weight category. On the other hand, the inhaled steroid resulted in a reduced effect in the percentage of ACDs among obese people i.e., the benefit of the inhaled steroid declined with increasing body mass index.

However, the study pointed out that the higher a person's body mass index, the greater his or her response to Singulair. Singulair is the brand name of montelukast sodium and is sold by Merck & Co., which funded this study.

First Published: Feb 24, 2006 12:01 IST