People with low birth weight are more likely to develop type 2 diabetes
People born with a low birth weight due to genetic factors may have an increased risk of developing type 2 diabetes, a new study has found.
Researchers from Tulane University in the US conducted the study on 3,627 type 2 diabetes cases and 12,974 controls of European ancestry.
They created a genetic risk score (GRS) based on five low birth weight-related genetic variations known as single nucleotide polymorphisms (SNPs). The analysis showed that for each one point increase in GRS (with the score ranging from 1-10), the risk of developing type 2 diabetes increased by 6%, researchers said.
Using a statistical technique called Mendelian randomisation, they further found evidence that the low birth-weight was actually causing the excess risk in type 2 diabetes.
This type of analysis, is, researchers said, a new approach for establishing causal relationships in studies of this nature.
“Evidence from both population and experimental studies has suggested that restricted early life development has long-term structural and functional influence on individuals’ predisposition to an increased risk of metabolic diseases such as type 2 diabetes,” researchers said.
“However, to our knowledge, this study is the first to investigate the potential causal relation between low birth-weight and risk of type 2 diabetes,” they added.
Since low birth-weight represents restricted intrauterine growth (foetal growth), it cannot be ruled out that it is in fact the risk factors for this restricted growth that are causing the low birth-weight and in turn causing type 2 diabetes to develop, researchers said.
Risk factors for restricted intrauterine growth include malnutrition, anaemia, infections and placental insufficiency, they said.
Researchers found that a genetically lowered birth weight was associated with increased susceptibility to type 2 diabetes.
“Our findings support a potential causal relation between birth weight and risk of type 2 diabetes, providing novel evidence to support the role of intrauterine exposures in the pathogenesis of type 2 diabetes,” researchers said.
The findings were published in the journal Diabetologia.
Enter your email to get our daily newsletter in your inbox
- Every week, fitness enthusiast Malaika Arora shares a new Yoga asana with her followers and urges them to exercise. However, this week, in order to celebrate International Women's Day she posted a picture of herself nailing the Reverse Warrior Pose and asked women to flaunt their warrior side.
- Disha Patani is known for her extreme workout sessions. The Bharat actor took to Instagram on International Women's Day and shared a glimpse from her martial arts session to show how strong she is.
- American actor and The Twilght Saga’s Rosalie Hale aka Nikki Reed flaunts her acro sport skills in latest fitness post as hubby and Vampire Diaries star Ian Somerhalder captures her in the middle of the jaw-dropping exercise move. Here’s why you should give Acro Yoga workout a try too
- Ishaan Khatter raises the bar of fitness motivation as we enter a new week and we are too inspired to follow his version of ‘when someone says let’s meet at the bar’. Here’s why
- Vicky Kaushal recently shared a glimpse of himself sweating it hard in the gym in order to earn his weekend cheat meal. We can say that the clip is inspiring us to start our Sunday with a fitness session as well.