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''Superpill' may cut heart disease'

Healthy people could cut their risk of heart disease in half with a new "super pill" that combines low doses of aspirin and drugs that lower blood pressure and cholesterol, says a study.

health and fitness Updated: Apr 01, 2009 15:55 IST

Healthy people could cut their risk of heart disease in half with a new "super pill" that combines low doses of aspirin and drugs that lower blood pressure and cholesterol, a study said Monday. "We believe that the polypill probably has the potential to reduce heart disease by 60 percent and stroke by 50 percent," lead investigator Salim Yusuf told reporters at the American College of Cardiology's annual meeting, where the study was presented.

"The thought that people might be able to take a single pill to reduce multiple cardiovascular risk factors has generated a lot of excitement. It could revolutionize heart disease prevention as we know it," Yusuf said. In the three-month study cardiologists compared the impact on blood pressure, cholesterol and heart rate of the combination "polypill" and the medications that make it up, taken individually or together.

The study involved 2,053 patients, recruited from heart centers around India between March 2007 and August 2008. The polypill contains low doses of three medications against high blood pressure; simvastatin, which lowers LDL -- or bad cholesterol -- and aspirin, a known blood-thinner.

"Before this study, there were no data about whether it was even possible to put five active ingredients into a single pill," the study said. "We found that it works," the researchers said. Participants in the study were divided into groups and given either the polypill or aspirin, the cholesterol-lowering medication, or one of the three blood pressure medications on their own; different combinations of blood pressure medications, or all three blood pressure treatments with or without aspirin.

The researchers found that blood pressure in participants in the polypill group was lowered as much as in the group taking the three blood pressure medications together, with or without aspirin.

Those blood pressure reductions "could theoretically lead to about a 24-percent risk reduction in congestive heart disease and 33 percent risk reduction in strokes in those with average blood pressure levels," the study said. The polypill reduced LDL cholesterol significantly more than in all other groups except the one in which simvastatin was taken alone.

The simvastatin group's LDL levels fell only slightly more than the polypill group, the study found. Heart rates in the polypill group and the group taking one of the blood-pressure medications, atenolol, fell by seven beats a minute -- significantly more than in the other study groups.

Side-effects in patients taking the polypill were the same as when taking one or two medications, the study found. "The side effects of one drug may be counteracted by beneficial effects of another. So the rate of stopping medications was the same," it said.

The study was "a critical first step to inform the design of larger, more definitive studies, as well as further development of appropriate combinations of blood-pressure lowering drugs with statins and aspirin," said Yusuf. Dr Christopher Cannon, a cardiologist from Harvard University, said the polypill took the medical world a step closer to beating heart disease, a leading cause of death worldwide.

Some 80 percent of heart disease cases are thought to occur in developing countries. "The concept is simple. Several different drugs are available (generically and thus inexpensively) to treat many of the cardiac risk factors. So, combining them in one pill could reduce heart disease by 80 percent," Cannon said in a comment piece in The Lancet, in which the results of the study were published.

"This approach has obvious appeal and vast implications for global health, because heart disease is the leading cause of death worldwide," he wrote.

First Published: Apr 01, 2009 15:53 IST