500m-yr-old mistake led to discovery of humans?
Over 500 million years ago, a spineless creature on the ocean floor experienced two successive doublings in the amount of its DNA, a “mistake” that eventually triggered the evolution of humans and many other animals, a new study has claimed.india Updated: Jul 25, 2012 18:47 IST
Over 500 million years ago, a spineless creature on the ocean floor experienced two successive doublings in the amount of its DNA, a “mistake” that eventually triggered the evolution of humans and many other animals, a new study has claimed.
An amphioxus (also called a lancelet), which is a very distant cousin to humans and other vertebrates. It is the creature most similar to the original spineless organism that existed before a major genomic event occurred.
The good news is that these ancient DNA doublings boosted cellular communication systems, so that our body cells are now better at integrating information than even the smartest smartphones.
The bad part is that communication breakdowns, traced back to the very same genome duplications of the Cambrian Period, can cause diabetes, cancer and neurological disorders.
“Organisms that reproduce sexually usually have two copies of their entire genome, one inherited from each of the two parents,” Discovery News quoted co-author Carol MacKintosh as saying.
“What happened over 500 million years ago is that this process ‘went wrong’ in an invertebrate animal, which somehow inherited twice the usual number of genes. In a later generation, the fault recurred, doubling the number of copies of each gene once again,” she said.
MacKintosh, a professor in the College of Life Sciences at the University of Dundee, said that such duplications also happened in plant evolution. As for the progeny of the newly formed animal, they remarkably survived and thrived.
“The duplications were not stable, however, and most of the resulting gene duplicates were lost quickly -- long before humans evolved,” MacKintosh said.
But some did survive, as MacKintosh and her team discovered.
Her research group studies a network of several hundred proteins that work inside human cells to coordinate their responses to growth factors and to insulin, a hormone. Key proteins involved in this process are called 14-3-3.
For this latest study, the scientists mapped, classified and conducted a biochemical analysis of the proteins. This found that they date back to the genome duplications, which occurred during the Cambrian.
The first animal to carry them remains unknown, but gene sequencing shows that a modern day invertebrate known as amphioxus “is most similar to the original spineless creature before the two rounds of whole genome duplication,” MacKintosh said.
“Amphioxus can therefore be regarded as a ‘very distant cousin’ to all the vertebrate (backboned) species,” she said.
The inherited proteins appear to have evolved to make a “team” that can tune into more growth factor instructions than would be possible with a single protein.
“These systems inside human cells therefore behave like the signal multiplexing systems that enable our smartphones to pick up multiple messages,” she shared.
The teamwork may not always be a good thing, though. The researchers propose that if a critical function were performed by a single protein, as in amphioxus, then its loss or mutation would likely be lethal, resulting in no disease.
If multiple proteins are working as a team, however, and one or more becomes lost or mutated, the individual may survive, but could still wind up with a debilitating disorder. Such breakdowns could help to explain how diseases, such as diabetes and cancer, are so entrenched in humans