California cardiologist with 20 years of experience explains 'unexpected side effects of melatonin no one talks about'

Dr Sanjay Bhojraj, a California-based cardiologist, said that long-term melatonin use (1+ year) may increase heart failure risk by 90 percent within 5 years.
Melatonin is a natural hormone that’s mainly produced by your pineal gland in your brain. It plays a role in managing your sleep-wake cycle and circadian rhythm, as per Cleveland Clinic. While scientists still have a lot to learn about all of its effects on the human body, Dr Sanjay Bhojraj, a cardiologist with 20 years of experience treating heart diseases, has warned about the long-term use of melatonin. Also read | Cardiac surgeon breaks down whether melatonin use is linked to increased risk of heart failure
Dr Bhojraj drops truth bombs about melatonin
Based in California, United States, Dr Bhojraj took to Instagram on November 14 to talk about the 'unexpected side effects of melatonin no one talks about'. He shared: “Do you take melatonin at night? The American Heart Association reviewed data from over 130,000 adults and found that long-term melatonin users (1+ year) had a 90 percent higher risk of heart failure within five years.”
“Now you might be thinking: 'Wait… isn’t melatonin natural?' It is. But so are cortisol, estrogen, and insulin...and when they’re out of rhythm, they can wreck your system too,” the cardiologist added.
‘Most people don’t have a melatonin deficiency'
Dr Bhojraj warned that taking melatonin nightly can disrupt circadian rhythm, alter hormone signaling, and reduce the body's own melatonin production, noting that most people don't have a melatonin deficiency, but rather a sleep rhythm problem.
He explained: “Your heart, mitochondria, and cellular repair systems all rely on precise hormonal timing. Taking melatonin nightly (especially long-term) can:
disrupt your circadian rhythm, alter natural hormone signaling, reduce your body’s ability to produce its own melatonin. Here’s the thing: most people don’t have a melatonin deficiency. They have a sleep rhythm problem.”
If you are using melatonin every night, click here to learn about possible long-term effects, common reactions, and when to consult a doctor for safe sleep support.
Note to readers: This report is based on user-generated content from social media. HT.com has not independently verified the claims and does not endorse them.
This article is for informational purposes only and not a substitute for professional medical advice.
ABOUT THE AUTHORSanya PanwarWith a keen eye for detail and a heart for storytelling, Sanya is a seasoned lifestyle journalist who has spent over a decade documenting the intersection of aesthetics and substance. Since stepping into the media world in 2012, she has cultivated a career defined by versatility, curiosity, and an unwavering passion for what makes life both beautiful and meaningful. Over the last many years, she has navigated the fast-paced realms of health, wellness, fitness and fashion while pivoting seamlessly into the nuances of decor and travel. Her work often explores the deeper layers of modern living, delving into art and decor trends that transform spaces, insightful perspectives on gender, parenting, and mental health, immersive travel narratives that capture the essence of a destination. A self-proclaimed aesthetics enthusiast, Sanya doesn't just report on trends — she analyses them. Whether she’s identifying the next shift in fitness or discovering a breakthrough in design, she uses her platform to spark meaningful conversations that resonate with a contemporary audience. Sanya is an alumna of St. Xavier’s College, Kolkata, and the Asian College of Journalism (ACJ), Chennai, where she honed the investigative rigour she brings to her lifestyle reporting today. When she isn't chasing deadlines or conducting interviews, Sanya practices what she preaches. You’ll likely find her sipping matcha, practicing yoga, or scouting the newest cafes. Above all, she finds her balance in nature — whether it's a quiet hike or a moment of reflection in the outdoors, she remains constantly inspired by the tranquillity of the natural world.Read More
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