San Francisco depth chart: Christian McCaffrey calf injury puts Week 1 status in doubt

San Francisco 49ers RB Christian McCaffrey was limited in practice on Thursday due to a calf issue. Full San Francisco 49ers Depth Chart.

Published on: Sep 5, 2025, 06:10:23 IST

By Vaishnavi Vaidyanathan

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The San Francisco 49ers will kick off their 2025 NFL season on the road against the division-rival Seattle Seahawks in a Week 1 showdown at Lumen Field on Sunday.

Christian McCaffrey #23 of the San Francisco 49ers suffered a calf injury. (Getty Images via AFP)

A key storyline ahead of Sunday’s game is the health status of star running back Christian McCaffrey, who appeared on the injury report for the first time this week. According to ESPN's NFL Insider Adam Schefter, McCaffrey was limited in practice on Thursday due to a calf issue. His availability for the season opener remains uncertain.

If McCaffrey is unable to play, Brian Robinson Jr. is expected to take over as the starting running back. Robinson, traded from the Washington Commanders during the offseason, is currently listed as McCaffrey’s primary backup. Behind him, Isaac Guerendo and Cody James would likely compete for additional snaps, while fullback Kyle Juszczyk could see an expanded role in a hybrid RB/FB capacity.

Full San Francisco 49ers Depth Chart

QB: Brock Purdy, Brandon Allen, Joshua Dobbs

RB: Christian McCaffrey, Brian Robinson Jr., Isaac Guerendo, Cody James, Kyle Juszczyk (FB)

WR: Jauan Jennings, Ricky Pearsall, Brandon Aiyuk (PUP), Demarcus Robinson (suspended), Jacob Cowing (IR), Jordan Watkins, Russell Gage, Ronnie Moore, Junior Bergen

TE: George Kittle, Eric Saubert, Jake Tonges, Brayden Willis

LT: Trent Williams, Jaylon Moore

LG: Aaron Banks, Ben Bartch

C: Jake Brendel, Nick Zakelj

RG: Dominick Puni, Spencer Burford

RT: Colton McKivitz, Brandon Parker Defense

LDE: Leonard Floyd, Yetur Gross-Matos, Robert Beal Jr.

LDT: Maliek Collins, Kalia Davis

RDT: Jordan Elliott, Khalil Davis

RDE: Nick Bosa, Sam Okuayinonu

WLB: De’Vondre Campbell, Dee Winters

MLB: Fred Warner, Curtis Robinson

SLB: Demetrius Flannigan-Fowles, Tatum Bethune

LCB: Charvarius Ward, Darrell Luter Jr.

RCB: Isaac Yiadom, Renardo Green

NB: Deommodore Lenoir, Rock Ya-Sin

FS: Ji’Ayir Brown, George Odum

SS: Talanoa Hufanga, Tayler Hawkins Special Teams

K: Jake Moody

P: Mitch Wishnowsky

LS: Taybor Pepper

KR/PR: Jacob Cowing (IR), Ronnie Moore, Junior Bergen

ABOUT THE AUTHOR
Vaishnavi Vaidyanathan
Vaishnavi Vaidyanathan leads the US Desk at Hindustan Times, where she writes, strategises coverage, and ensures quality across all beats. With eight years of experience covering US news for leading publications, she has reported extensively on politics, entertainment, and sports. Vaishnavi holds a graduate degree in English, Journalism, and Psychology, and completed her PG Diploma in Broadcast Journalism from the Manorama School of Communication, where she was awarded the prestigious Mammen Mappillai Award for Best Outgoing Student. She began her career at the International Business Times (US Edition), covering US breaking news, politics, and entertainment. She later joined Opoyi, reporting across all beats, including US sports and trending stories. Prior to Hindustan Times, she served as World Lead at Times Now News, covering comprehensive world news and events. Vaishnavi has expertise in politics, entertainment, and breaking news, and enjoys tackling stories across a wide range of topics. Beyond the newsroom, she is an avid traveller, a foodie who loves exploring new restaurants, and a pop culture enthusiast who enjoys watching latest shows and films. She also enjoys engaging in debates and discussions on Reddit.Read More

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