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Gastroenterologist reveals why the timing for taking supplements also matters for best results

Most of us are not aware of the science behind vitamin and mineral supplement absorption. Gastroenterologist Dr. Saurabh Sethi explains why timing is important.

Published on: Aug 27, 2025 03:54 PM IST
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You may be taking your vitamin and mineral supplements everyday but do you take them at the correct time? Many people assume that supplements work the same way no matter when they’re consumed, but the truth is, they might as well underperform or even cause side effects like digestive issues if not taken at the right time or paired with the right nutrients.

Gastroenterologist breaks down the mechanism behind supplement absorption and why timing matter. (Unsplash)
Gastroenterologist breaks down the mechanism behind supplement absorption and why timing matter. (Unsplash)

Gastroenterologist Dr. Saurabh Sethi, who trained at AIIMS, Harvard, and Stanford Universities, has listed the optimal timing and pairings for various vitamin and mineral supplements to maximize their effectiveness and minimize side effects. In an Instagram video posted on August 27, Dr. Sethi provided a guide to optimize your supplementation to get better results, including which ones to take in an empty stomach and the food pairings to add or avoid.

Pair iron with vitamin C

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Vitamin B complex

The best time to take vitamin B complex, as recommended by Dr. Sethi, is in the morning since it helps support energy production and metabolism for the rest of the day. A report published on Medical News Today further explains that research indicates vitamin B-6 can potentially interfere with sleep, by inducing vivid dreams - hence it is safer to take vitamin B supplements right after waking up in the morning.

Calcium

According to Dr. Sethi, the best time to take calcium supplements is in the evening or paired with meals. This way, it is easier on the stomach. Moreover, calcium plays an important role in the sleep-wake cycle, by helping the synthesis of melatonin, as per an article on VeryWell Health reviewed by dietician Allison Herries - so it is better to take calcium close to bedtime. However, the gastroenterologist warns against pairing calcium with iron since the former decreases iron absorption.

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Zinc

Dr. Sethi recommends taking zinc supplements along with food, preferably at dinner time. Zinc has the tendency of causing nausea or stomach discomfort in some people, and pairing it with food helps decrease the discomfort. More reason to take zinc supplements during dinner is that, like calcium, it absorbs better when kept separate from iron.

Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. It is based on user-generated content from social media. HT.com has not independently verified the claims and does not endorse them.

 
ABOUT THE AUTHOR
Eshana Saha

Eshana Saha is a fresh face in lifestyle and cultural journalism, bringing a refined, multidisciplinary perspective to the intersection of entertainment, fashion and holistic wellbeing. With less than a year of professional experience, she has quickly adapted to high-pressure editorial environments and currently works full-time with HT Media. Prior to this, she interned for nearly six months with Hindustan Times’ entertainment and lifestyle vertical, where she gained hands-on experience in digital reporting, trend analysis and editorial storytelling. Based in New Delhi, Eshana specialises in comprehensive coverage of major cultural moments — from international film press tours to the curated aesthetics of global fashion showcases, award shows and music-centred events. She holds a Bachelor’s degree in English from St Xavier’s University, Kolkata, and a Master’s degree in English from the University of Delhi, equipping her with a strong academic foundation and a keen ability to deconstruct complex cultural trends into clear, high-impact narratives. Beyond the red carpet, Eshana has developed a growing focus on health and wellbeing reporting. She bridges the gap between celebrity-driven trends and practical, evidence-informed lifestyle advice, ensuring her work remains both aspirational and grounded in editorial rigour. She has extensively covered the health implications of Delhi’s air pollution crisis, while also playing a key role in amplifying expert-led insights on women’s health and mental wellbeing, helping translate complex medical perspectives into informed, impactful public awareness. An artist at heart, she explores multiple creative forms — from visual arts and music to culinary experiments — and brings a creative’s eye for nuance, texture and detail to every story. Whether analysing runway dynamics or examining emerging wellness movements, she remains committed to accuracy and the highest standards of contemporary journalistic ethics.

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Catch your daily dose of Fashion, Taylor Swift, Health, Festivals, Travel, Relationship, Recipe and all the other Latest Lifestyle News on Hindustan Times Website and APPs.
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