IIT Roorkee to conduct research for identifying antiviral to tackle COVID-19
Indian Institute of Technology (IIT) Roorkee will conduct research on the identification of antiviral to treat COVID-19.
This development comes after a proposal led by Professor Pravindra Kumar has been given a go-ahead by the Science and Engineering Research Board (SERB).
“The study will identify small molecule inhibitors to target key viral replication enzymes- RNA dependent RNA polymerase (nsp12), viral proteases (Mpro and PL2pro) and the Methyltransferase or MTase (nsp14),” an official release said.
“These enzymes are virus-specific that are encoded with genetic material (RNA) of the viral pathogens. Virus-specific protease catalyses the cleavage of specific peptide bonds in viral polyproteins. The study will be funded under the intensification of Research in high-priority areas (IRHPA) under the Department of Science and Technology (DST),” it said.
The objective of the study is to identify antiviral molecules to combat COVID-19 and it will expedite the process of identification of drugs through an in-silico approach that is based on computer-aided simulation of their molecular structures.
“I would like to thank the Science and Engineering Research Board for reposing faith in us,” said Prof. Kumar, Department of Biotechnology, IIT Roorkee.
The groundwork of the research has already been prepared by the completion of in silico work based on high throughput virtual screening approach to assess the binding affinity of the Food and Drug Administration (FDA)-approved drugs targeting Mpro -- a viral protease.
The study will leverage a computer-based high throughput virtual screening approach to identify antiviral molecules from various compound libraries that will be validated for antiviral potential, the release said.
It will be conducted in collaboration with Prof. Shailly Tomar, Dept of Biotechnology, IIT Roorkee, and Dr Gaurav Sharma from the Indian Veterinary Research Institute (IVRI), Izatnagar who will aid in the assessment of the antiviral efficacy of the identified molecule to treat SARS-CoV2.
“This approach can be path-breaking in the identification of antiviral molecules to fight COVID-19,” said Prof. Ajit K Chaturvedi, Director, IIT Roorkee.
Enter your email to get our daily newsletter in your inbox
- Interested and eligible candidates can apply for the positions through a prescribed format on or before February 28, 2021.
- After the correction window opens, candidates who have registered for the JEE Mains 2021 will be able to make corrections in their application forms online at jeemain.nta.nic.in on or before January 30, 2021.
- Candidates who have registered for the typing test can download their admit card online at gjust.ac.in.
- Candidates who have appeared in the recruitment examination can take a print out of the final answer key online at ssc.nic.in on or before February 24, 2021.
- Candidates who have qualified in the IBPS PO Prelims Exam can download their admit card for IBPS PO mains online at ibps.in on or before February 4, 2021.
- Candidates who have applied for admission can check the AP EAMCET second phase allotment result 2020 online at apeamcet.nic.in.
- Patnaik had launched the "Mo School" campaign in November 2017 in response to philanthropic interest from alumni of schools of Odisha, residing in India and abroad.
- Universities need to explore the uncharted path and innovative methods when it comes to pedagogy, and playing the role of facilitators in a student's journey of finding their goals and preparing them for their future.