Cefazolin facts

Cefazolin is used in treatment of infections caused by E.coli, Klebsiella, Aureus and influenza.

Systems: General (Systemic)
Category: First Generation Cephalosporin

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Pharmacokinetics

Cefazolin is administered parentrally .It reaches high concentrations in plasma and bile.Cefazolin has a longer half life( 2 hrs )hence used in surgical prophylaxis.80 % is protein bound. 90 % is excreted in the urine.

Indications

Cefazolin is used in the treatment of infections caused by E.coli, Klebsiella, Staphylococcus Aureus, H.influenza.

Routes of Administration and Dosage

250 milligrams eighth hourly in milder cases or 1 gm sixth hourly in severe cases I.M or I.V .

Contra Indications

Cefazolin is contraindicated in pregnancy, lactation, hypersensitivity and during concurrent administration of diuretics.

Precautions

Precautions are to be taken in Renal disease .

Interactions

Probenecid increases the blood level of Cefazolin. Concurrent use of diuretic with Cefazolin may increase the nephrotoxicity.

Brand Names

Alcizon(Alembic), Azolin(Biochem), Cefamezin(Rallis), Cezolin (Lupin), Orizolin(Alidac), Prezolin(Prem Pharma), Prilex(Hindustan), Reflin(Ranbaxy).

(Source: Webhealthcentre.com)