San Francisco 49ers injury report: Brock Purdy among players ruled out for Week 2

Brock Purdy is out for Week 2 vs. Saints. 49ers also list Jauan Jennings and Trent Williams as questionable, both limited in Friday's practice.

Published on: Sep 14, 2025, 10:17:12 IST

By HT News Desk

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The San Francisco 49ers are preparing to face the New Orleans Saints on Sunday (September 14). After quarterback Brock Purdy was ruled out, the 49ers realized they had much bigger problems to focus on as well. Jauan Jennings and Trent Williams currently remain questionable for the upcoming game as 9 other players remain on the latest report. Their participation status in the game is likely to be updated closer to the date.

Brock Purdy #13 of the San Francisco 49ers reacts during the second quarter against the Seattle Seahawks during the game at Lumen Field on September 07, 2025 in Seattle, Washington. (Getty Images via AFP)

Here is the full and latest injury report, as published by the official 49ers website:

Ben Bartch

Offensive line

INJURY: Knee, elbow

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Nick Bosa

Defensive lineman

INJURY: Resting player

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Luke Gifford

Linebacker

INJURY: Knee

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Yetur Gross-Matos

Defensive lineman

INJURY: Knee

LATEST UPDATE: Limited participation in practice

GAME STATUS: Not listed

Jordan James

Running back

INJURY: Finger

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Also Read: Cowboys vs. Giants full injury report: Who's in, who's out for tonight’s matchup

Mac Jones

Quarterback

INJURY: Knee

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Jauan Jennings

Running back

INJURY: Shoulder

LATEST UPDATE: Limited participation in practice

GAME STATUS: Questionable

Christian McCaffrey

Running back

INJURY: Calf, resting player

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Dominick Puni

Offensive lineman

INJURY: Knee

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Brock Purdy

Quarterback

INJURY: Left shoulder, toe

LATEST UPDATE: Did not participate in practice

GAME STATUS: Out

Jordan Watkins

Wide receiver

INJURY: Ankle

LATEST UPDATE: Full participation in practice

GAME STATUS: Not listed

Trent Williams

Tackle

INJURY: Knee, resting player

LATEST UPDATE: Limited participation in practice

GAME STATUS: Questionable

If WR Russell Gage isn’t moved up, chances of Jennings going on next to WRs Ricky Pearsall, Kendrick Bourne, Marquez Valdes-Scantling and Skyy Moore are high. If Williams ends up skipping this one, Spencer Burford would likely be the next top option for starting left tackle.

The 49ers are scheduled to take on the Saints in their next season outing at Caesars Superdome.

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HT News Desk
Follow the latest breaking news, major developments and agenda-setting stories from India and around the world with the newsdesk at Hindustan Times. Operating round the clock, the desk brings together experienced editors, reporters and correspondents to deliver fast, accurate and contextual reporting across subjects that influence public policy, governance, business, society and international affairs. The HT News Desk covers politics, elections, government policies, the economy, business and markets, science and technology, the environment, law and order, infrastructure, education, climate issues and geopolitics, while closely tracking developments across states, institutions and global capitals. The team also leads coverage of major breaking news events, policy announcements, court proceedings, natural disasters, public emergencies and significant international developments. Reports published by the newsdesk are based on information gathered from reporters on the ground, official statements, government agencies, court records, regulatory filings, recognised institutions and other authoritative sources. Stories undergo editorial scrutiny and verification processes to ensure accuracy, fairness and relevance, and are updated as events evolve and additional information becomes available. Whether covering a key political decision in New Delhi, an economic policy shift affecting millions, a landmark court ruling or a major global event, the HT News Desk aims to provide readers with reliable, fact-based journalism that delivers not only the latest developments but also the context and analysis needed to understand their wider implications.Read More

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