Cephalothin is used only parenterally. It is 70% protein bound. Plasma half life is 45 minutes.health and fitness Updated: Mar 01, 2004 18:12 IST
Systems: General (Systemic)
Category: First Generation Cephalosporin. It was the first cephalosporin to be used clinically.
Cephalothin is used only parenterally.It is 70% protein bound.Plasma half life is 45 minutes.
Cephalothin is used in the treatment of infections caused by Gram positive organisms like pneumococci, Streptococcus Viridians, Staphylococcus Aureus and gram negative organisms like E.coli, Klebsiella pneumoniae and Proteus mirabilis.
Routes of Administration and Dosage
Adults;1-2 gms I.V.every 6th hourly.Children;50-150 mgs/kg/day.
Cephalothin is contraindicated in pregnancy, lactation, hypersensitivity and in pseudomembranous colitis.
Precaution to be taken are during renal disease (when the dose needs to be reduced) and in Gastro-intestinal diseases (especially colitis, enteritis) .
Probenecid increases the blood level of Cephalothin.