Marvin Harrison Jr. appendicitis surgery: Big blow for Cardinals fans, WR's status for Week 11 revealed
Cardinals’ promising young receiver faces an injury setback at a critical juncture for the franchise
Marvin Harrison Jr., the rising star wide receiver for the Arizona Cardinals, will be unable to play in Sunday's pivotal matchup against the San Francisco 49ers after undergoing an emergency surgery for appendicitis earlier this week, Coach Jonathan Gannon said Wednesday.

The 23-year-old has 525 receiving yards and four touchdowns in the first nine games of the 2025 season, making him the focal point of the Cardinals' offence. His sudden absence from the game leaves Arizona's receiving corps shorthanded at a crucial time in the season.
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When will Marvin Harrison Jr. be back?
Harrison, shortly after being sidelined for appendicitis, underwent surgery on Monday night, November 10. The team confirmed his absence for this weekend's game but left the door open for a return later in the season.
“We’ll see,” Gannon said when asked if Harrison could miss more than one game.
It marks the first time in his young career that Harrison Jr. will miss a regular-season contest, highlighting the severity of the issue.
Harrison has tallied 34 catches for 525 yards across nine appearances and ranks second on the team behind tight end Trey McBride. With star teammate Zay Jones sidelined for the season with a torn Achilles, the Cardinals’ depth at receiver has already been strained.
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Harrison Jr's absence a big blow for Cardinals
Harrison's absence is at a crucial time for the Cardinals. The team is navigating both offensive personnel shifts and declining fortunes.
The team holds a 3-6 record and is already working without starting quarterback Kyler Murray, who is out with a foot injury, leaving Jacoby Brissett under center.
Niners Nation reports that losing Harrison further limits the passing game, forcing the offence to lean heavily on McBride and a thin group of receivers, including Michael Wilson and Greg Dortch. The change in dynamics could hamper Arizona’s ability to keep pace in the competitive NFC.
ABOUT THE AUTHORShirin GuptaShirin Gupta is a content producer with the Hindustan Times. She covers everything between politics, entertainment and sports at the US desk. Shirin got interested in political journalism during her time as a web editor at her college newspaper NCC News in Syracuse when she first started seeing the effects of national politics in life of her fellow colleagues. Shirin has worked on a wide range of fast-moving and developing stories locally when she was at NCC editing accessible reports for the audience. Her current role requires her to track real-time updates, verify information and present balanced coverage across diverse beats. Covering US politics from an international newsroom perspective has further deepened her understanding of how domestic decisions can have far-reaching global consequences. With a keen interest in international affairs, Shirin continues to build her expertise in geopolitics, policy shifts, and cross-border developments. She aims to learn and evolve her reporting in matters of geopolitics and international issues. Outside the newsroom Shirin writes about books and music for her personal blog. She is an avid consumer of pop culture and reveres literature.Read More

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