After defining extensive cellular heterogeneity, researchers from The University of Texas MD Anderson Cancer Center developed a tool that might be useful in stratifying patients with gastric cancer and directing them for more effective treatment strategies.(ANI)
After defining extensive cellular heterogeneity, researchers from The University of Texas MD Anderson Cancer Center developed a tool that might be useful in stratifying patients with gastric cancer and directing them for more effective treatment strategies.(ANI)

Scientists develop tool for treating tumor cells found in gastric cancer

After defining extensive cellular heterogeneity, researchers from The University of Texas MD Anderson Cancer Center developed a tool that might be useful in stratifying patients with gastric cancer and directing them for more effective treatment strategies.
ANI
PUBLISHED ON JAN 10, 2021 04:35 PM IST

After defining extensive cellular heterogeneity, researchers from The University of Texas MD Anderson Cancer Center developed a tool that might be useful in stratifying patients with gastric cancer and directing them for more effective treatment strategies.

Based on the findings, published in Nature Medicine, the scientists developed and validated a gene expression signature capable of predicting patient survival better than other clinical features.

"In order to better treat patients with PC, we first have to understand the populations of metastatic cells in the peritoneal cavity," said co-corresponding author Linghua Wang, M.D., PhD, assistant professor of Genomic Medicine."This is the most detailed analysis of these cells performed to date. That is the power of single-cell analysis - we are able to look at every single cell and get a picture of the landscape," added Wang.

Peritoneal carcinomatosis is a condition in which cancer cells infiltrate and invade the peritoneal, or abdominal, cavity, adhering to the stomach and other organs.This can occur with other gastrointestinal cancers but is most commonly seen in patients with advanced gastric cancers, with roughly 45 per cent of patients diagnosed with PC at some point. The condition leads to significant fluid accumulation in the abdominal cavity, and patients have an overall survival of fewer than six months.

"PC represents a major unmet clinical need, as we don't have effective treatment options available for these patients," said co-corresponding author Jaffer Ajani, M.D., professor of Gastrointestinal Medical Oncology."Based on our findings, we need to move toward profiling these cells in each patient in order to offer more tailored treatment options," added Anjani.

For this study, the researchers isolated PC cells from ascites fluid collected from 20 patients with advanced gastric cancer. Ten of the patients were long-term survivors who survived more than one year after PC diagnosis, and 10 patients were short-term survivors who survived less than six months after PC diagnosis.

After performing single-cell RNA sequencing to analyze gene expression, the researchers were able to build the first "map" of PC cells, which describes the variety of cell types present and their functional states. The variability of cancer cells present within a tumour is known as intratumor heterogeneity, and it can lead to treatment failure and recurrence as distinct subtypes of cancer cells will respond differently to a given therapy.

The gene expression information also enabled the researchers to determine the origins of the PC cells, known as tumour cell lineage. They discovered that, although these were all gastric cancer cells, some appeared to originate from cells of the stomach while others more closely resembled cells of the intestine.

"The intriguing aspect is that, by classifying tumour cells based on lineage compositions, we noted two groups of patients," Wang said. "The more gastric-like PC cells had an aggressive phenotype and were associated with shorter survival. However, the more intestine-like PC cells were less aggressive, and patients had longer survival."

Based on these findings, the researchers developed a gene signature which robustly predicted patient survival better than various clinical features. They validated the signature in the second cohort of patients with advanced gastric cancer and PC and four large-scale localized gastric cancer cohorts totalling more than 1,300 patients.

Going forward, the researchers hope to validate the signature in prospective studies and to perform further analyses of PC cells in more patients to identify regulatory mechanisms of tumour cell lineage plasticity and new therapeutic targets that can be exploited to provide better treatment options for patients.

"This is an important first step toward a better understanding of the single-cell biology of these cancer cells, but we have more work to do. We foresee that understanding this heterogeneity could one day be used to guide clinical decision making that is most beneficial to each patient," Ajani said.

This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.

SHARE THIS ARTICLE ON
app
Close
Immunotherapies are cancer drugs that essentially block the "don't-eat-me" signal coming from cancer and allow the immune-system to kill it. (Representative Image)(ANI)
Immunotherapies are cancer drugs that essentially block the "don't-eat-me" signal coming from cancer and allow the immune-system to kill it. (Representative Image)(ANI)

Researchers find how cancer can be killed by body's own immune system

ANI
PUBLISHED ON JAN 17, 2021 03:12 PM IST
In a previous study, scientists at the Cancer Research Center and the University of Missouri developed a genetically distinct and non-toxic strain of salmonella called CRC2631 to select and kill cancer cells.
Close
Painters refurbish the NASA logo on the Vehicle Assembly Building at the Kennedy Space Center in Florida.(AFP)
Painters refurbish the NASA logo on the Vehicle Assembly Building at the Kennedy Space Center in Florida.(AFP)

NASA test of mega Moon rocket engines cut short

AFP
PUBLISHED ON JAN 17, 2021 12:54 PM IST
  • Despite being cut short, NASA said the test of the RS-25 engines had provided valuable information for the planned missions.
Close
Space Launch System's hot fire test, expected to begin at 5 pm(@NASA/Twitter )
Space Launch System's hot fire test, expected to begin at 5 pm(@NASA/Twitter )

NASA's Boeing moon rocket set for 'once-in-a-generation' ground test

Reuters, Washington
PUBLISHED ON JAN 16, 2021 07:33 PM IST
The expendable super heavy-lift SLS is three years behind schedule and nearly $3 billion over budget.
Close
An innovative way to learn about the elements of the periodic table has been introduced through a study led by researchers of American Chemical Society (ACS).(ANI)
An innovative way to learn about the elements of the periodic table has been introduced through a study led by researchers of American Chemical Society (ACS).(ANI)

Scientists introduce new twist to learning periodic table

ANI
PUBLISHED ON JAN 16, 2021 05:09 PM IST
An innovative way to learn about the elements of the periodic table has been introduced through a study led by researchers of American Chemical Society (ACS).
Close
Scientists studying the body's natural defenses against bacterial infection have identified a nutrient, taurine that helps the gut recall prior infections and kill invading bacteria, such as Klebsiella pneumoniae (Kpn).(ANI)
Scientists studying the body's natural defenses against bacterial infection have identified a nutrient, taurine that helps the gut recall prior infections and kill invading bacteria, such as Klebsiella pneumoniae (Kpn).(ANI)

Scientists identify nutrient that helps prevent bacterial infection

ANI
UPDATED ON JAN 16, 2021 04:10 PM IST
Scientists studying the body's natural defenses against bacterial infection have identified a nutrient, taurine that helps the gut recall prior infections and kill invading bacteria, such as Klebsiella pneumoniae (Kpn).
Close
Malaria killed more than 400,000 people across the world in 2019, according to the latest WHO figures, all but a few thousand of them in Africa. There were 229 million cases across the world, 215 million of them on the continent.(Representative image)
Malaria killed more than 400,000 people across the world in 2019, according to the latest WHO figures, all but a few thousand of them in Africa. There were 229 million cases across the world, 215 million of them on the continent.(Representative image)

South African scientists discover new chemicals that kill malaria parasite

Reuters, Johannesburg
UPDATED ON JAN 15, 2021 10:11 PM IST
The World Health Organisation said in November that deaths from malaria due to disruption during the coronavirus pandemic to services designed to tackle the mosquito-borne disease will far exceed those killed by Covid-19 in sub-Saharan Africa.
Close
Scientists from Max Planck Institute for Chemical Ecology describe how the plants produce defensive toxins without harming themselves and the exact mode of action of diterpene glycosides in wild tobacco.(ANI)
Scientists from Max Planck Institute for Chemical Ecology describe how the plants produce defensive toxins without harming themselves and the exact mode of action of diterpene glycosides in wild tobacco.(ANI)

Study elucidates how production of defensive toxins takes place in plants

ANI
UPDATED ON JAN 15, 2021 07:12 PM IST
Scientists from Max Planck Institute for Chemical Ecology describe how the plants produce defensive toxins without harming themselves and the exact mode of action of diterpene glycosides in wild tobacco.
Close
A team of scientists and doctors from the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust have developed a DNA test which they claim will quickly identify secondary infections in Covid-19 patients, who have double the risk of developing pneumonia while on ventilation.(ANI)
A team of scientists and doctors from the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust have developed a DNA test which they claim will quickly identify secondary infections in Covid-19 patients, who have double the risk of developing pneumonia while on ventilation.(ANI)

DNA test can identify pneumonia in Covid-19 patients, aiding treatment: Study

ANI
UPDATED ON JAN 15, 2021 06:32 PM IST
A team of scientists and doctors from the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust have developed a DNA test which they claim will quickly identify secondary infections in Covid-19 patients, who have double the risk of developing pneumonia while on ventilation.
Close
According to the findings of the new study researchers have identified a promising new model in order to study the human aging process.(ANI)
According to the findings of the new study researchers have identified a promising new model in order to study the human aging process.(ANI)

Study identifies promising model for human aging

ANI
PUBLISHED ON JAN 15, 2021 10:52 AM IST
According to the findings of the new study researchers have identified a promising new model in order to study the human aging process.
Close
2020 edged out 2016 by a very small amount, within the margin of error of the analysis, making the years effectively tied for the warmest year on record.(BLOOMBERG)
2020 edged out 2016 by a very small amount, within the margin of error of the analysis, making the years effectively tied for the warmest year on record.(BLOOMBERG)

NASA analysis shows 2020 tied for warmest year on record

ANI
PUBLISHED ON JAN 15, 2021 10:23 AM IST
Washington [US], January 15 (ANI): Earth's global average surface temperature in 2020 tied with 2016 as the warmest year on record, according to an analysis by NASA.
Close
NASA's InSight spacecraft at Vandenberg Air Force Base in California in May 2018 (Bill Ingalls/NASA via AP))(AP)
NASA's InSight spacecraft at Vandenberg Air Force Base in California in May 2018 (Bill Ingalls/NASA via AP))(AP)

NASA's Mars digger bites the dust after 2 years on red planet

AP
PUBLISHED ON JAN 15, 2021 09:07 AM IST
The team called it quits following one last unsuccessful attempt over the weekend to burrow deep into Mars.
Close
A team of researchers from the University of Warwick has pinpointed the three days when pregnancy sickness, characterised by nausea and vomiting, is most likely to start.(ANI)
A team of researchers from the University of Warwick has pinpointed the three days when pregnancy sickness, characterised by nausea and vomiting, is most likely to start.(ANI)

Researchers pinpoint three days when pregnancy is most likely to start

ANI
PUBLISHED ON JAN 14, 2021 06:11 PM IST
A team of researchers from the University of Warwick has pinpointed the three days when pregnancy sickness, characterised by nausea and vomiting, is most likely to start.
Close
The combined effectiveness of three Covid prevention strategies on college campuses, mask wearing, social distancing, and routine testing, are effective in preventing coronavirus infections as the Pfizer and Moderna vaccines approved by the Food and Drug Administration (FDA), according to a study.(ANI)
The combined effectiveness of three Covid prevention strategies on college campuses, mask wearing, social distancing, and routine testing, are effective in preventing coronavirus infections as the Pfizer and Moderna vaccines approved by the Food and Drug Administration (FDA), according to a study.(ANI)

Study: Colleges can prevent 96 pc of COVID-19 infections with common measures

ANI
UPDATED ON JAN 13, 2021 05:40 PM IST
The combined effectiveness of three Covid prevention strategies on college campuses, mask wearing, social distancing, and routine testing, are effective in preventing coronavirus infections as the Pfizer and Moderna vaccines approved by the Food and Drug Administration (FDA), according to a study.
Close
A study led by researchers at Ohio State University highlights an unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress, that the pressure used to inflate the lungs is likely to cause further lung damage.(ANI)
A study led by researchers at Ohio State University highlights an unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress, that the pressure used to inflate the lungs is likely to cause further lung damage.(ANI)

Study sheds light on ventilator-induced lung injuries

ANI
UPDATED ON JAN 13, 2021 12:43 PM IST
A study led by researchers at Ohio State University highlights an unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress, that the pressure used to inflate the lungs is likely to cause further lung damage.
Close
Researchers from the Northwestern University claims that Covid-19 pneumonia spreads like multiple wildfires, leaving destroyed lung tissue in its wake.(ANI)
Researchers from the Northwestern University claims that Covid-19 pneumonia spreads like multiple wildfires, leaving destroyed lung tissue in its wake.(ANI)

Covid-19 pneumonia causes more damage than typical pneumonia, says study

ANI
UPDATED ON JAN 13, 2021 11:49 AM IST
Researchers from the Northwestern University claims that Covid-19 pneumonia spreads like multiple wildfires, leaving destroyed lung tissue in its wake.
Close
SHARE
Story Saved
OPEN APP