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Did you know strong legs signal sharper brain? AIIMS-trained gastroenterologist explains and shares 5 leg exercises

Updated on: Apr 1, 2026, 14:31:57 IST
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Working out the legs can ultimately benefit the brain. (Pexel)
Working out the legs can ultimately benefit the brain. (Pexel)

Leg strength has been linked to cognitive health in decade long study. Dr Saurabh Sethi explains the findings. 

Cognitive health has long been a growing concern for individuals as they age. Maintaining it requires leading a healthy lifestyle that ensures adequate nutrition and exercise.

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Surprisingly, cognitive health is also aided by ensuring that one’s legs are in great shape, according to Dr Saurabh Sethi, a California-based gastroenterologist trained in AIIMS, Harvard, and Stanford Universities. Taking to Instagram on April 1, Dr Sethi explained the science behind the claim and shared a list of exercises that will allow us to build leg strength.

Study shows connection between leg strength and cognitive health

Dr Sethi revealed that researchers studied 324 female twins over 10 years to understand what predicts cognitive ageing. The reason for conducting the study on twins was that it provided a control for genetics. The factors that researchers tracked include:

“Same genes. Same upbringing. Different leg strength,” noted Dr Sethi. “The result? The twin with stronger legs had more grey matter and a larger hippocampus”, which is the memory centre of the brain.

The study showed that the leg strength of an individual was predictive of the following:

  • 10-year cognitive change
  • Total grey matter volume
  • Lateral ventricle size (a marker of brain ageing)

The finding held true even after the acquired data were adjusted for heart disease, diabetes, blood pressure, diet, smoking, alcohol, IQ, and socioeconomic status.

Explaining the muscle-mind connection

Dr Sethi shared three reasons why leg strength was found to be related to cognitive health.

1. Neural stem cell signalling

Leg exercises send signals to your brain that trigger new cell production,” shared the gastroenterologist, noting that restricting leg movements results in a 70 percent drop in neural stem cells.

2. BDNF release

Lower body training boosts BDNF, short for brain-derived neurotrophic factor. It is a protein that helps neurons grow and connect. According to Dr Sethi, legs have four times more effect on boosting BNDF than the muscles in the upper body, simply because they are bigger in size.

3. Increased blood flow

Bigger muscles result in bigger cardiovascular demand, which leads to more oxygen and nutrients reaching the brain. This is essential for neuronal health & repair.

Five exercises to build leg strength

  1. Squats: Go deep, add weight over time
  2. Leg press: Mimics the exact movement tested in the study
  3. Step-ups: Single-leg power that translates to real life
  4. Lunges: The deeper you go, the more power you build
  5. Box jumps: Train the fast-twitch fibres that decline with age

Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

This report is based on user-generated content from social media. HT.com has not independently verified the claims and does not endorse them.

  • Debapriya Bhattacharya
    ABOUT THE AUTHOR
    Debapriya Bhattacharya

    Debapriya Bhattacharya is a Content Producer at Hindustan Times. He started his career in 2022, working in newsrooms in beats like education, US news, trending stories, and entertainment. In his new role in the lifestyle desk, he seeks to deliver a balanced blend of research-driven reporting and creative storytelling from health and recipes to art and culture. Science, philosophy, food and pop culture are what pump his veins and help bring heart to his stories. Debapriya tries to see out subjects that will allow him and readers to explore new frontiers and improve the quality of life for all. The explorations can be both external and internal, as thoughts seek to be as chaotic as the greater universe. As a citizen of the world, Debapriya has been fascinated by the lives of people across the globe throughout time. His curiosity leads him to explore new linguistic and cultural landscapes to broaden his horizons and deepen his understanding of global narratives. Beyond the newsroom, Debapriya loves to participate in debate and theatre, spaces that he considers to be holy grounds for nuance and self-expression. A graduate from Ashutosh College, University of Calcutta, Debapriya completed his Master's degree from the same university in 2022. An ambiverted bibliophile, he loves his solitude as much as he adores stimulating conversations. And despite his reverence for tech, libraries continue to be his favourite place for research.Read More

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